2-[1-Methoxy-1-[3-(3-phenyl-2-propynyloxy)phenyl]propyl]thiazole

Base Information

Chemical Name:2-[1-Methoxy-1-[3-(3-phenyl-2-propynyloxy)phenyl]propyl]thiazole
CAS No.:129424-10-8
Molecular Formula:C₂₂H₂₁NO₂S
Molecular Weight:363.48
Hs Code.:
ChEMBL ID:CHEMBL327926
DSSTox Substance ID:DTXSID701157396
Nikkaji Number:J423.798F
Pharos Ligand ID:9K41V53JWUU3

Synonyms:CHEMBL327926;129424-10-8;SCHEMBL9369635;DTXSID701157396;2-[1-Methoxy-1-[3-(3-phenyl-2-propynyloxy)phenyl]propyl]thiazole;BDBM50000831;2-[1-Methoxy-1-[3-[(3-phenyl-2-propyn-1-yl)oxy]phenyl]propyl]thiazole;2-{1-Methoxy-1-[3-(3-phenyl-prop-2-ynyloxy)-phenyl]-propyl}-thiazole

Suppliers and Price of 2-[1-Methoxy-1-[3-(3-phenyl-2-propynyloxy)phenyl]propyl]thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[1-Methoxy-1-[3-(3-phenyl-2-propynyloxy)phenyl]propyl]thiazole

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:363.12930009
Heavy Atom Count:26
Complexity:493

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(C1=CC(=CC=C1)OCC#CC2=CC=CC=C2)(C3=NC=CS3)OC

Technology Process of 2-[1-Methoxy-1-[3-(3-phenyl-2-propynyloxy)phenyl]propyl]thiazole

There total 11 articles about 2-[1-Methoxy-1-[3-(3-phenyl-2-propynyloxy)phenyl]propyl]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 129424-07-3
3-<1-methoxy-1-(thiazol-2-yl)propyl>phenol

: 1794-48-5
1-bromo-3-phenylprop-2-yne

: 129424-10-8
2-[1-methoxy-1-[3-(3-phenylprop-2-ynyloxy)phenyl]propyl]thiazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1021/jm00111a038

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 129424-10-8
2-[1-methoxy-1-[3-(3-phenylprop-2-ynyloxy)phenyl]propyl]thiazole

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h

3: 100 percent / DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -55 - -50 °C

4: 91 percent / diethyl ether / 1 h / Ambient temperature

5: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h

6: 76 percent / H₂ / 30percent Pd/C / ethyl acetate

7: 100 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

With n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; potassium carbonate; dimethyl sulfoxide; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038

Reference yield:

: 1700-37-4
3-Benzyloxybenzaldehyde

: 129424-10-8
2-[1-methoxy-1-[3-(3-phenylprop-2-ynyloxy)phenyl]propyl]thiazole

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h

2: 100 percent / DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -55 - -50 °C

3: 91 percent / diethyl ether / 1 h / Ambient temperature

4: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h

5: 76 percent / H₂ / 30percent Pd/C / ethyl acetate

6: 100 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

With n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; potassium carbonate; dimethyl sulfoxide; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038