Technology Process of 2α-benzoyloxy-4α,13α-dihydroxy-5β,20-epoxy-11-taxen-10-one
There total 15 articles about 2α-benzoyloxy-4α,13α-dihydroxy-5β,20-epoxy-11-taxen-10-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
toluene;
at 0 ℃;
for 2h;
DOI:10.1080/00397910701569767
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 81.3 percent / 4-methylmorpholine N-oxide monohydrate / tetrapropylammonium perruthenate / tetrahydrofuran / 10 h / 20 °C
2: 84.8 percent / AcOH; H2O / tetrahydrofuran / 8 h / 45 °C
3: 80.8 percent / pyridine / 24 h / 20 °C
4: 61.7 percent / K2CO3; H2O / methanol; tetrahydrofuran / 0.5 h / -10 °C
5: DBU / toluene / 2 h / 105 °C
6: 40 mg / DCC; 4-(dimethylamino)pyridine / acetonitrile / 24 h / 0 °C
7: 71.4 percent / Red-Al / toluene / 2 h / 0 °C
With
pyridine; dmap; water; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4-methylmorpholine 4-oxide monohydrate; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride;
tetrapropylammonium perruthennate;
In
tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1080/00397910701569767
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 79.9 percent / TBAF*3H2O / tetrahydrofuran / 10 h / 20 °C
2: 81.3 percent / 4-methylmorpholine N-oxide monohydrate / tetrapropylammonium perruthenate / tetrahydrofuran / 10 h / 20 °C
3: 84.8 percent / AcOH; H2O / tetrahydrofuran / 8 h / 45 °C
4: 80.8 percent / pyridine / 24 h / 20 °C
5: 61.7 percent / K2CO3; H2O / methanol; tetrahydrofuran / 0.5 h / -10 °C
6: DBU / toluene / 2 h / 105 °C
7: 40 mg / DCC; 4-(dimethylamino)pyridine / acetonitrile / 24 h / 0 °C
8: 71.4 percent / Red-Al / toluene / 2 h / 0 °C
With
pyridine; dmap; tetrabutyl ammonium fluoride; water; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4-methylmorpholine 4-oxide monohydrate; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride;
tetrapropylammonium perruthennate;
In
tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1080/00397910701569767
