4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine

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Chemical Name:4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine
CAS No.:1332837-44-1
Molecular Formula:C₁₅H₁₂Cl₂FN₃O
Molecular Weight:340.184
Hs Code.:

Synonyms:4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine

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Chemical Property of 4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine

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Technology Process of 4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine

There total 6 articles about 4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1332837-58-7
C₂₀H₁₉Cl₃FN₃O₃

: 1332837-44-1
4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine

Guidance literature:: C₂₀H₁₉Cl₃FN₃O₃; With hydrogenchloride; zinc; In 1,4-dioxane; water; for 1.5h;

With sodium hydrogencarbonate; In 1,4-dioxane; water;

Reference yield:

: 425380-38-7
4-bromo-7-chloro-3a,7a-dihydro-1H-pyrrolo[2,3-c]pyridine

: 1332837-44-1
4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / tetrahydrofuran / 1 h

2.1: bis(pinacol)diborane; potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

2.2: 4 h / 0 °C

3.1: toluene-4-sulfonic acid; nickel(II) nitrate hexahydrate / 1 h / Reflux

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 20 °C

5.1: zinc; acetic acid / 16 h / 20 °C

6.1: hydrogenchloride; zinc / 1,4-dioxane; water / 1.5 h

With hydrogenchloride; dmap; nickel(II) nitrate hexahydrate; di-isopropyl azodicarboxylate; potassium acetate; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; bis(pinacol)diborane; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; water; 4.1: Mitsunobu reaction;

Reference yield:

: 1332837-54-3
C₁₂H₁₂BrClN₂O₂

: 1332837-44-1
4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis(pinacol)diborane; potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

1.2: 4 h / 0 °C

2.1: toluene-4-sulfonic acid; nickel(II) nitrate hexahydrate / 1 h / Reflux

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 20 °C

4.1: zinc; acetic acid / 16 h / 20 °C

5.1: hydrogenchloride; zinc / 1,4-dioxane; water / 1.5 h

With hydrogenchloride; nickel(II) nitrate hexahydrate; di-isopropyl azodicarboxylate; potassium acetate; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; bis(pinacol)diborane; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; 3.1: Mitsunobu reaction;