1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine

Base Information

Chemical Name:1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine
CAS No.:1410789-70-6
Molecular Formula:C₃₀H₃₇NO
Molecular Weight:427.63
Hs Code.:

1-{4-[α-(1-tricyclo[3.3.1.1<sup>3,7</sup>]decyl)phenylmethyl]phenylacetyl}pirerazine

Synonyms:1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine

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Chemical Property of 1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine

Chemical Property:

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Technology Process of 1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine

There total 9 articles about 1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 110-89-4
piperidine

: C₂₅H₂₇ClO

: 1410789-70-6
1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 12h; Reflux;
DOI:10.1021/jm3013008

Reference yield:

: 1410789-53-5
α-(4-bromophenyl)-α-phenyl-1-tricyclo[3.3.1.1^3,7]-decanemethanol

: 1410789-70-6
1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

1.3: 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane; N,N-dimethyl-formamide / 2 h / -80 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: potassium tert-butylate / 1,2-dimethoxyethane; methanol / 2 h / -60 - 80 °C / Inert atmosphere

4.1: hydrogenchloride; water / 3 h / Reflux

5.1: sodium hydroxide / ethanol; water / 2 h / Reflux

5.2: 0 °C

6.1: thionyl chloride / 1 h / 60 °C

7.1: tetrahydrofuran / 12 h / 0 - 20 °C / Reflux

With hydrogenchloride; n-butyllithium; thionyl chloride; potassium tert-butylate; water; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3013008

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 1410789-70-6
1-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylacetyl}pirerazine

Guidance literature:: Multi-step reaction with 10 steps

1.1: magnesium / diethyl ether / Inert atmosphere; Reflux

1.2: 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

2.3: 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane; N,N-dimethyl-formamide / 2 h / -80 - 20 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux

4.2: 0 °C

5.1: thionyl chloride; calcium carbonate; calcium chloride / diethyl ether / 12 h / 20 °C

6.1: dimethyl sulfoxide / 12 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / 3 h / Reflux

8.1: sodium hydroxide / ethanol; water / 2 h / Reflux

8.2: 0 °C

9.1: thionyl chloride / 1 h / 60 °C

10.1: tetrahydrofuran / 12 h / 0 - 20 °C / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; water; magnesium; trifluoroacetic acid; calcium carbonate; calcium chloride; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm3013008