1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide

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Chemical Name:1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide
CAS No.:1621268-57-2
Molecular Formula:C₂₇H₂₄FN₇O₂
Molecular Weight:497.532
Hs Code.:

Synonyms:1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide

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Chemical Property of 1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide

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Technology Process of 1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide

There total 5 articles about 1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 3832-36-8
2-fluoro-N-methylethan-1-amine hydrochloride

: 1621268-56-1
1-benzyl-5-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

: 1621268-57-2
1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 16h;

Reference yield:

: 1621268-54-9
2-benzyl-2H-pyrazole-3,4-dicarboxylic acid 4-ethyl ester

: 1621268-57-2
1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / 2 h / 50 °C

2: pyridine / 0.17 h / 0 - 25 °C

3: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 25 °C

4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 25 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 2-[1-(dimethylamino)meth-(Z)-ylidene]-3-oxosuccinic acid diethyl ester

: 1621268-57-2
1-benzyl-4-N-(2-fluoroethyl)-4-N-methyl-5-N-{2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-1H-pyrazole-4,5-dicarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / ethanol; water / 12 h / 25 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 - 25 °C

3: oxalyl dichloride / 2 h / 50 °C

4: pyridine / 0.17 h / 0 - 25 °C

5: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 25 °C

6: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 25 °C

With pyridine; hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;