(1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester

Base Information

Chemical Name:(1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester
CAS No.:179944-87-7
Molecular Formula:C₁₆H₁₉NO₅
Molecular Weight:305.331
Hs Code.:

Synonyms:(1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester

Suppliers and Price of (1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester

There total 2 articles about (1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18717-72-1
(-)-norcocaine

: 179944-87-7
(1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 0.8 N HCl / Heating

2: Na₂CO₃ / H₂O / 3 h / Ambient temperature

With hydrogenchloride; sodium carbonate; In water;
DOI:10.1021/jo960522q

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 28393-47-7
N-Norecgonine

: 179944-87-7
(1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester

Guidance literature:: With sodium carbonate; In water; for 3h; Yield given; Ambient temperature;
DOI:10.1021/jo960522q

Reference yield:

: 179944-87-7
(1R,2R,3S,5S)-3-Hydroxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-benzyl ester

: 1026857-20-4
6-{[(1R,2R,3S,5S)-3-(Methoxy-phenyl-phosphinoyloxy)-8-aza-bicyclo[3.2.1]octane-2-carbonyl]-amino}-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: iPr₂EtN, tetrazole / benzene / 1 h

2: 20 percent

3: DCC, Et₃N / CH₂Cl₂ / Ambient temperature

4: 0.222 g / H₂ / Pd/C / methanol / 2 h

With 1H-tetrazole; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; benzene;
DOI:10.1021/jo960522q