[4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid

Base Information

Chemical Name:[4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid
CAS No.:1131803-25-2
Molecular Formula:C₂₄H₂₉ClN₄O₆SSi
Molecular Weight:565.122
Hs Code.:

[4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid

Synonyms:[4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid

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Chemical Property of [4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid

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Technology Process of [4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid

There total 13 articles about [4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 950662-58-5
[4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid ethyl ester

: 1131803-25-2
[4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid

Guidance literature:: [4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid ethyl ester; With methanol; sodium hydroxide; water; at 20 ℃; for 2h;

With hydrogenchloride; water;

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 1131803-25-2
[4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic acid; N-chloro-succinimide / acetonitrile / 16 h / 20 °C

2: phosphorus pentoxide / chloroform / 0 - 20 °C / Inert atmosphere

3: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 1.5 h / 80 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C

6: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

7: sodium hydroxide / water; methanol / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-chloro-succinimide; n-butyllithium; Triisopropyl borate; phosphorus pentoxide; sodium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 4: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.08.050

Reference yield:

: 950661-64-0
4-chloro-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1131803-25-2
[4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-5-cyano-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / -78 - 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.03 h / -78 °C

2.2: -78 - 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.17 h

3.2: 0.25 h / 20 °C

4.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 1.5 h / 80 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C

7.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

8.1: sodium hydroxide / water; methanol / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; sodium hydride; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 5.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.08.050