tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate
CAS No.:1610520-46-1
Molecular Formula:C₂₆H₃₃N₃O₅S
Molecular Weight:499.631
Hs Code.:

Synonyms:tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

: 1610520-45-0
7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1610520-46-1
tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate

Guidance literature:: 7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde; 1-t-Butoxycarbonylpiperazine; With acetic acid; In dichloromethane; for 0.166667h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 40 ℃; for 1h; Temperature;

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610520-46-1
tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

5.1: acetic acid / dichloromethane / 0.17 h

5.2: 1 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; n-butyllithium; potassium carbonate; caesium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water;

Reference yield:

: 1610520-27-8
4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 1610520-46-1
tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

2.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

2.2: 20 °C

3.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

4.1: acetic acid / dichloromethane / 0.17 h

4.2: 1 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; potassium carbonate; caesium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;