N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester

Base Information

• Chemical Name: N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester
• CAS No.: 619337-64-3
• Molecular Formula: C₂₂H₂₅NO₅
• Molecular Weight: 383.444
• Mol file: 619337-64-3.mol

Synonyms:N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester

Chemical Property of N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester

There total 6 articles about N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

N-(O-benzylterephthaloyl)-D-leucine 3,5-dimethylphenyl ester (619337-62-1) → N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester (619337-64-3)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; under 750.075 Torr;

DOI:10.1002/chem.200304783

Reference yield:

Z-D-Leu-OH (28862-79-5) → N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester (619337-64-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 60.8 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexaflu; orophosphate; N-methyl morpholine / CH₂Cl₂ / 20 °C

2: 71.9 percent / aq. HBr / acetic acid / 3 h / 20 °C

3: 92.3 percent / chlorotripyrrolidinophosphonium hexafluorophosphate; N-methyl morpholine / CH₂Cl₂ / 20 °C

4: 94.8 percent / H₂ / Pd(OH)2/C / ethanol / 750.08 Torr

With 4-methyl-morpholine; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexaflu; orophosphate; hydrogen bromide; hydrogen; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; palladium dihydroxide; In ethanol; dichloromethane; acetic acid;

DOI:10.1002/chem.200304783

Reference yield:

monobenzyl terephthalate (18520-63-3) → N-terephthaloyl-D-leucine 3,5-dimethylphenyl ester (619337-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 92.3 percent / chlorotripyrrolidinophosphonium hexafluorophosphate; N-methyl morpholine / CH₂Cl₂ / 20 °C

2: 94.8 percent / H₂ / Pd(OH)2/C / ethanol / 750.08 Torr

With 4-methyl-morpholine; hydrogen; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; palladium dihydroxide; In ethanol; dichloromethane;

DOI:10.1002/chem.200304783

upstream raw materials:

N-(O-benzylterephthaloyl)-D-leucine 3,5-dimethylphenyl ester

Z-D-Leu-OH

monobenzyl terephthalate

3,5-Dimethylphenol