(R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one

Base Information

Chemical Name:(R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one
CAS No.:107659-43-8
Molecular Formula:C₂₄H₁₄BrCl₄N₃O₃
Molecular Weight:614.109
Hs Code.:

Synonyms:(R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one

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Chemical Property of (R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one

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Technology Process of (R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one

There total 6 articles about (R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1633-33-6
4-bromobenzoic anhydride

: 94171-15-0,107658-58-2,107741-26-4
(R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propan-1-one

: 107659-43-8
(R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00389a016

Reference yield:

: 104941-05-1
1,2-Bis-(2,4-dichloro-phenyl)-propenone

: 107659-43-8
(R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / NaBH₄, CeCl₃*7H₂O / methanol / 0 - 5 °C

2: 38 percent / (+)-diisopropyl L-tartrate, Ti(O-i-Pr)4, t-butyl hydroperoxide / CH₂Cl₂; various solvent(s) / 15 h / -20 °C

3: 98 percent / PCC / CH₂Cl₂ / 18 h / Ambient temperature

4: NaH / dimethylformamide / 4 h / 60 °C

5: 35 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; sodium tetrahydroborate; cerium(III) chloride; L-(+)-diisopropyl tartrate; sodium hydride; triethylamine; pyridinium chlorochromate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00389a016

Reference yield:

: 107680-34-2
2-(2,4-dichlorophenyl)-2',4'-dichloroacetophenone

: 107659-43-8
(R)-(-)-1,2-bis(2,4-dichlorophenyl)-2-<(4-bromobenzoyl)-oxy>-3-(1H-1,2,4-triazol-1-yl)propan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 66 percent / acetic anhydride / 0.5 h / 50 °C

2: 58 percent / NaBH₄, CeCl₃*7H₂O / methanol / 0 - 5 °C

3: 38 percent / (+)-diisopropyl L-tartrate, Ti(O-i-Pr)4, t-butyl hydroperoxide / CH₂Cl₂; various solvent(s) / 15 h / -20 °C

4: 98 percent / PCC / CH₂Cl₂ / 18 h / Ambient temperature

5: NaH / dimethylformamide / 4 h / 60 °C

6: 35 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; sodium tetrahydroborate; cerium(III) chloride; L-(+)-diisopropyl tartrate; sodium hydride; triethylamine; pyridinium chlorochromate; In methanol; dichloromethane; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1021/jm00389a016