2,6-DIFLUORO-BENZAMIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 2,6-DIFLUORO-BENZAMIDINE HYDROCHLORIDE
• CAS No.: 304867-43-4
• Molecular Formula: C₇H₆F₂N₂*ClH
• Molecular Weight: 192.596
• Mol file: 304867-43-4.mol

Synonyms:Benzenecarboximidamide,2,6-difluoro-, monohydrochloride (9CI)

Chemical Property of 2,6-DIFLUORO-BENZAMIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 49.87000
• LogP: 2.85090

Purity/Quality:

98%min ^*data from raw suppliers

2,6-DifluorobenzenecarboximidamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIFLUORO-BENZAMIDINE HYDROCHLORIDE

There total 1 articles about 2,6-DIFLUORO-BENZAMIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,6-difluoro-benzaldehyde oxime (19064-16-5) → 2,6-difluorobenzimidamide hydrochloride (304867-43-4)

Guidance literature:

2,6-difluoro-benzaldehyde oxime; With tert-butylhypochlorite; ammonia;

With hydrogenchloride; hydrogen; nickel; In ethanol;

DOI:10.2533/000942903777678560

Reference yield:

mucobromic acid (488-11-9) + 2,6-difluorobenzimidamide hydrochloride (304867-43-4) → 5-bromo-2-(2,6-difluorophenyl)pyrimidine-4-carboxylic acid (1052714-35-8)

Guidance literature:

2,6-difluorobenzimidamide hydrochloride; With sodium ethanolate; In ethanol; at 0 - 20 ℃; for 1h;

mucobromic acid; In ethanol; at 40 ℃; for 2h;

DOI:10.1021/acs.jmedchem.0c01279

upstream raw materials:

2,6-difluoro-benzaldehyde oxime

Downstream raw materials:

5-bromo-2-(2,6-difluorophenyl)pyrimidine-4-carboxylic acid

Refernces