α-Pyrrolidinopropiophenone (hydrochloride)

Base Information

• Chemical Name: α-Pyrrolidinopropiophenone (hydrochloride)
• CAS No.: 92040-10-3
• Molecular Formula: C₁₃H₁₇NO*ClH
• Molecular Weight: 239.745
• Mol file: 92040-10-3.mol

Synonyms:(SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone hydrochloride

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Chemical Property of α-Pyrrolidinopropiophenone (hydrochloride)

Chemical Property:

• Flash Point: 9℃
• Storage Temp.: ?20°C

Purity/Quality:

Safty Information:

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

Useful:

• Description: α-Pyrrolidinopropiophenone (hydrochloride) is an analog of the appetite suppressant diethylcathinone and is related to the designer drug 4’-methyl-α-pyrrolidinopropiophenone (MPPP). In male Wistar rats, it is metabolized to a variety of products, including cathinone, the main psychoactive alkaloid of kath (Catha edulis). α-Pyrrolidinopropiophenone (hydrochloride) is intended to be used for forensic applications.

Technology Process of α-Pyrrolidinopropiophenone (hydrochloride)

There total 4 articles about α-Pyrrolidinopropiophenone (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1SR,2RS)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol hydrochloride → (SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone hydrochloride (92040-10-3)

Guidance literature:

(1SR,2RS)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol hydrochloride; With sodium dichromate; sulfuric acid; In water; at 15 - 20 ℃; for 12.3333h;

With sodium hydroxide; In water; toluene; at 20 ℃; pH=10.5;

With hydrogenchloride; In water; toluene; pH=2;

DOI:10.1016/j.tetasy.2009.11.019

Reference yield:

(SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone (19134-50-0) → (SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone hydrochloride (92040-10-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol;

DOI:10.1016/j.neuropharm.2021.108570

Reference yield:

2-bromo-1-phenyl-1-propanone (2114-00-3) → (SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone hydrochloride (92040-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: hydrogenchloride / methanol; 1,4-dioxane

With hydrogenchloride; In 1,4-dioxane; methanol; ethanol;

DOI:10.1016/j.neuropharm.2021.108570

upstream raw materials:

1-phenyl-propan-1-one

(SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone

2-bromo-1-phenyl-1-propanone

Downstream raw materials:

1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol