N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

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Chemical Name:N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine
CAS No.:1401732-63-5
Molecular Formula:C₂₆H₂₉FN₆O
Molecular Weight:460.554
Hs Code.:

Synonyms:N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

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Chemical Property of N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

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Technology Process of N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

There total 4 articles about N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221198-99-8
1-(2-fluoro-4-aminophenyl)-4-methylpiperazine

: 1111638-42-6
5-bromo-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

: 1401732-63-5
N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

Guidance literature:: With potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 90 ℃; for 12h; Inert atmosphere; Sealed tube;

Reference yield:

: 62908-83-2
3-methyl-5-nitropyrazolo<3,4-b>pyridine

: 1401732-63-5
N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal / ethanol / 5 h / 20 °C

2.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

3.2: 0 - 20 °C / Reflux

4.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere; Sealed tube

With potassium tert-butylate; hydrogen bromide; sodium hydride; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; copper(I) bromide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil; 4.1: Buckwald-Hartwig;

Reference yield:

: 1186608-73-0
3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

: 1401732-63-5
N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

2.2: 0 - 20 °C / Reflux

3.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere; Sealed tube

With potassium tert-butylate; hydrogen bromide; sodium hydride; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; copper(I) bromide; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 3.1: Buckwald-Hartwig;