2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile

Base Information

Chemical Name:2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile
CAS No.:1198439-37-0
Molecular Formula:C₄₁H₅₀N₂O₂Si₂
Molecular Weight:659.031
Hs Code.:

Synonyms:2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile

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Chemical Property of 2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile

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Technology Process of 2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile

There total 1 articles about 2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2-({5-[(1R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl](4S,1R,5R)-2-hydroxy-4-(1-methyl-1-phenyl-1-silaethyl)cyclohexyl}benzylamino)ethanenitrile

: 1198439-37-0
2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile

Guidance literature:: 2-({5-[(1R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl](4S,1R,5R)-2-hydroxy-4-(1-methyl-1-phenyl-1-silaethyl)cyclohexyl}benzylamino)ethanenitrile; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - -10 ℃; Inert atmosphere;
DOI:10.1021/ol902373m

Reference yield: 73.0%

: 1198439-38-1
(Z)-6-iodohepta-1,5-diene

: 1198439-37-0
2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile

: 1198439-40-5
2-(benzyl((1R,2S,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-((Z)-hepta-2,6-dien-2-yl)-2-hydroxycyclohexyl)amino)acetonitrile

Guidance literature:: 2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile; With cerium(III) chloride bis(lithium chloride); In tetrahydrofuran; at 25 ℃; for 2h; Inert atmosphere;

(Z)-6-iodohepta-1,5-diene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; Inert atmosphere;

With acetic acid; In tetrahydrofuran; methanol; water; pentane; at -78 ℃; Inert atmosphere;
DOI:10.1021/ol902373m

Reference yield: 71.0%

: 1198439-57-4
(Z)-1-((5-iodohex-4-enyloxy)methyl)benzene

: 1198439-37-0
2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile

: 2-(benzyl((1R,2S,4S,5R)-2-((Z)-6-(benzyloxy)hex-2-en-2-yl)-5-((R)-1-(tertbutyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-hydroxycyclohexyl)amino)acetonitrile

Guidance literature:: 2-(benzyl((1R,4S,5R)-5-((R)-1-(tert-butyldiphenylsilyloxy)ethyl)-4-(dimethyl(phenyl)silyl)-2-oxocyclohexyl)amino)acetonitrile; With cerium(III) chloride bis(lithium chloride); In tetrahydrofuran; at 25 ℃; for 2.5h; Inert atmosphere;

(Z)-1-((5-iodohex-4-enyloxy)methyl)benzene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; Inert atmosphere;

With acetic acid; In tetrahydrofuran; methanol; water; pentane; at -78 ℃; Inert atmosphere;
DOI:10.1021/ol902373m