1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

Base Information

Chemical Name:1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone
CAS No.:145364-16-5
Molecular Formula:C₂₅H₂₇FN₄O
Molecular Weight:418.514
Hs Code.:

Synonyms:1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

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Chemical Property of 1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

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Technology Process of 1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

There total 6 articles about 1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[3-(4-Fluoro-phenyl)-7-methyl-indol-1-yl]-1-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-pyridinium; iodide

: 145364-16-5
1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 3.5h;
DOI:10.1021/jm00104a007

Reference yield:

: 19524-06-2
4-bromopyridine hydrochloride

: 145364-16-5
1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃, CuBr / various solvent(s) / 18 h / Heating

2: various solvent(s) / 6 h / Heating

3: NaBH₄ / ethanol / 3.5 h

With sodium tetrahydroborate; potassium carbonate; copper(I) bromide; In ethanol;
DOI:10.1021/jm00104a007

Reference yield:

: 145364-08-5
3-(4-fluorophenyl)-7-methyl-1H-indole

: 145364-16-5
1-<2-<4-<3-(4-fluorophenyl)-7-methyl-1H-indol-1-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃, CuBr / various solvent(s) / 18 h / Heating

2: various solvent(s) / 6 h / Heating

3: NaBH₄ / ethanol / 3.5 h

With sodium tetrahydroborate; potassium carbonate; copper(I) bromide; In ethanol;
DOI:10.1021/jm00104a007