(2S,10S)-N¹-cyclopropylmethyl-N⁴,N⁸-dibenzyl-2,10-dihydroxy-N¹¹-ethylnorspermine

Base Information

• Chemical Name: (2S,10S)-N¹-cyclopropylmethyl-N⁴,N⁸-dibenzyl-2,10-dihydroxy-N¹¹-ethylnorspermine
• CAS No.: 357383-49-4
• Molecular Formula: C₂₉H₄₆N₄O₂
• Molecular Weight: 482.71

Synonyms:(2S,10S)-N¹-cyclopropylmethyl-N⁴,N⁸-dibenzyl-2,10-dihydroxy-N¹¹-ethylnorspermine

Chemical Property of (2S,10S)-N¹-cyclopropylmethyl-N⁴,N⁸-dibenzyl-2,10-dihydroxy-N¹¹-ethylnorspermine

Chemical Property:

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Technology Process of (2S,10S)-N¹-cyclopropylmethyl-N⁴,N⁸-dibenzyl-2,10-dihydroxy-N¹¹-ethylnorspermine

There total 8 articles about (2S,10S)-N¹-cyclopropylmethyl-N⁴,N⁸-dibenzyl-2,10-dihydroxy-N¹¹-ethylnorspermine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(2R,10R)-N1,N11-bis(trifluoromethanesulfonyl)-N1-cyclopropylmethyl-N4,N8-dibenzyl-2,10-dihydroxy-N11-ethylnorspermine (357383-48-3) → (2S,10S)-N1-cyclopropylmethyl-N4,N8-dibenzyl-2,10-dihydroxy-N11-ethylnorspermine (357383-49-4)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; Heating;

DOI:10.1021/jm000532q

Reference yield:

N,N'-dibenzyl-1,3-diaminopropane (10239-34-6) → (2S,10S)-N1-cyclopropylmethyl-N4,N8-dibenzyl-2,10-dihydroxy-N11-ethylnorspermine (357383-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / ethanol / Heating

2: 94 percent / ethanol / 72 h / Heating

3: 60 percent / red-Al / toluene / Heating

With sodium bis(2-methoxyethoxy)aluminium dihydride; In ethanol; toluene;

DOI:10.1021/jm000532q

Reference yield:

N-[(2S)-2,3-epoxypropyl]-N-ethyltrifluoromethanesulfonamide (259656-88-7) → (2S,10S)-N1-cyclopropylmethyl-N4,N8-dibenzyl-2,10-dihydroxy-N11-ethylnorspermine (357383-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / ethanol / Heating

2: 94 percent / ethanol / 72 h / Heating

3: 60 percent / red-Al / toluene / Heating

With sodium bis(2-methoxyethoxy)aluminium dihydride; In ethanol; toluene;

DOI:10.1021/jm000532q

upstream raw materials:

(2R,10R)-N¹,N¹¹-bis(trifluoromethanesulfonyl)-N¹-cyclopropylmethyl-N⁴,N⁸-dibenzyl-2,10-dihydroxy-N¹¹-ethylnorspermine

N,N'-dibenzyl-1,3-diaminopropane

N-[(2S)-2,3-epoxypropyl]-N-ethyltrifluoromethanesulfonamide

N-cyclopropylmethyl-N-[(2S)-2,3-epoxypropyl]trifluoromethanesulfonamide

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