methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate

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Chemical Name:methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate
CAS No.:882687-28-7
Molecular Formula:C₂₉H₃₀Br₂N₂O₇
Molecular Weight:678.374
Hs Code.:

Synonyms:methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate

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Chemical Property of methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate

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Technology Process of methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate

There total 4 articles about methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: benzyl {3-[2,4-dibromo-6-(2-methyl-5-oxooxazol-4-ylidenemethyl)phenoxy]propyl}carbamate

: O-(4-methoxybenzyl)-hydroxylamine HCl

: 18107-18-1
diazomethyl-trimethyl-silane

: 882687-28-7
methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate

Guidance literature:: benzyl {3-[2,4-dibromo-6-(2-methyl-5-oxooxazol-4-ylidenemethyl)phenoxy]propyl}carbamate; With barium dihydroxide; In 1,4-dioxane; at 60 ℃; for 1h;

O-(4-methoxybenzyl)-hydroxylamine HCl; In 1,4-dioxane; at 60 ℃; for 13h;

diazomethyl-trimethyl-silane; In methanol; hexane; benzene; at 20 ℃; for 0.666667h;
DOI:10.1021/jm051030l

Reference yield:

: 882687-29-8
benzyl [3-(2,4-dibromo-6-formylphenoxy)propyl]carbamate

: 882687-28-7
methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / NaOAc; Ac₂O / 4 h / 120 °C

2.1: aq. Ba(OH)2 / dioxane / 1 h / 60 °C

2.2: dioxane / 13 h / 60 °C

2.3: 32 percent / benzene; methanol; hexane / 0.67 h / 20 °C

With barium dihydroxide; sodium acetate; acetic anhydride; In 1,4-dioxane;
DOI:10.1021/jm051030l

Reference yield:

: 90-59-5
3,5-Dibromosalicylaldehyde

: 882687-28-7
methyl 3-[2-(3-benzyloxycarbonylaminopropoxy)-3,5-dibromophenyl]-2-(4-methoxybenzyloxyimino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / K₂CO₃ / dimethylformamide / 4 h / 100 °C

2.1: 85 percent / NaOAc; Ac₂O / 4 h / 120 °C

3.1: aq. Ba(OH)2 / dioxane / 1 h / 60 °C

3.2: dioxane / 13 h / 60 °C

3.3: 32 percent / benzene; methanol; hexane / 0.67 h / 20 °C

With barium dihydroxide; sodium acetate; acetic anhydride; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm051030l