(2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol

Base Information

Chemical Name:(2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol
CAS No.:321921-91-9
Molecular Formula:C₂₂H₃₆O₃Si
Molecular Weight:376.612
Hs Code.:

Synonyms:(2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol

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Chemical Property of (2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol

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Technology Process of (2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol

There total 12 articles about (2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 251319-65-0
(2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dienoic acid methyl ester

: 321921-91-9
(2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1016/S0040-4020(00)00804-8

Reference yield:

: 88738-78-7
bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate

: 251319-56-9
(2R,3R,4E)-2-methyl-3-(tert-butyldimethylsilyloxy)-6-(phenylmethoxy)hex-4-en-1-al

: 321921-91-9
(2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol

Guidance literature:: bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate; (2R,3R,4E)-2-methyl-3-(tert-butyldimethylsilyloxy)-6-(phenylmethoxy)hex-4-en-1-al; With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃;

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;
DOI:10.1016/S0040-4039(99)01481-1

Reference yield:

: 69152-87-0
4-benzyloxycrotonaldehyde

: 321921-91-9
(2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: dibutylboron triflate / CH₂Cl₂ / 0.5 h / 0 °C

1.2: 100 percent / CH₂Cl₂ / 1.5 h / -78 - 0 °C

2.1: Al(CH₃)3 / tetrahydrofuran; toluene / 2.5 h / 0 °C

2.2: aq. HCl / CH₂Cl₂ / 18 h / 0 °C

3.1: 14.1 g / imidazole / dimethylformamide / 18 h

4.1: 10.7 g / DIBAL / tetrahydrofuran / 1 h / -78 °C

5.1: 89 percent / potassium hexamethyldisilazide; 18-crown-6 / tetrahydrofuran / 0.5 h / -78 °C

6.1: 100 percent / DIBAL / CH₂Cl₂ / 0.25 h / -78 °C

With 1H-imidazole; 18-crown-6 ether; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: deprotonation / 1.2: Addition / 2.1: Substitution / 2.2: Hydrolysis / 3.1: Substitution / 4.1: Reduction / 5.1: Condensation / 6.1: Reduction;
DOI:10.1016/S0040-4020(00)00804-8