(4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate

Base Information

Chemical Name:(4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate
CAS No.:1227492-03-6
Molecular Formula:C₂₅H₂₃NO₄
Molecular Weight:401.462
Hs Code.:

Synonyms:(4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate

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Chemical Property of (4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate

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Technology Process of (4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate

There total 7 articles about (4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.3%

: 370103-09-6
(2S,3R)-benzyl 2-(2-(benzyloxy)phenylamido)-3-hydroxybutanoate

: 1227492-03-6
(4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate

Guidance literature:: With thionyl chloride; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

: 1056310-66-7
C₂₅H₂₅NO₅

: 1227492-03-6
(4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate

Guidance literature:: C₂₅H₂₅NO₅; With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;

With potassium carbonate; In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/j.ejmech.2009.12.074

Reference yield:

: 55142-16-0
methyl 2-(benzyloxy)benzoate

: 1227492-03-6
(4S,5S)-benzyl 2-(2-(benzyloxy)phenyl)-5-methyl-4,5-dihydrooxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol / 20 °C

2.1: triethylamine / dichloromethane / 0.17 h

2.2: Cooling with ice

3.1: thionyl chloride / dichloromethane / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; sodium hydroxide; In methanol; dichloromethane;