C₁₅H₁₉NO₃S

Base Information

• Chemical Name: C₁₅H₁₉NO₃S
• CAS No.: 1374550-46-5
• Molecular Formula: C₁₅H₁₉NO₃S
• Molecular Weight: 293.387
• Mol file: 1374550-46-5.mol

Synonyms:C₁₅H₁₉NO₃S

Chemical Property of C₁₅H₁₉NO₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₉NO₃S

There total 7 articles about C₁₅H₁₉NO₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

N-(4-(1-hydroxycyclobutyl)but-3-yn-1-yl)-4-methylbenzenesulfonamide (1374550-49-8) → C15H19NO3S (1374550-46-5)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; sodium hydrogencarbonate; In tetrachloromethane; at 20 ℃; for 4h; Molecular sieve;

DOI:10.1002/asia.201101029

Reference yield:

1-(4-hydroxybut-1-yn-1-yl)cyclobutan-1-ol (1374550-54-5) → C15H19NO3S (1374550-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: triethylamine / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

4: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; sodium hydrogencarbonate / tetrachloromethane / 4 h / 20 °C / Molecular sieve

With (triphenylphosphine)gold(I) chloride; di-isopropyl azodicarboxylate; silver trifluoromethanesulfonate; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; 1: Mitsunobu reaction;

DOI:10.1002/asia.201101029

Reference yield:

N-(p-toluenesulfonyl)aziridine (3634-89-7) → C15H19NO3S (1374550-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -20 °C / Inert atmosphere

1.2: 2 h / -20 - 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol

3.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; sodium hydrogencarbonate / tetrachloromethane / 4 h / 20 °C / Molecular sieve

With n-butyllithium; (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; tetrachloromethane;

DOI:10.1002/asia.201101029

upstream raw materials:

N-(4-(1-hydroxycyclobutyl)but-3-yn-1-yl)-4-methylbenzenesulfonamide

1-(4-hydroxybut-1-yn-1-yl)cyclobutan-1-ol

C₈H₁₃NO

N-(p-toluenesulfonyl)aziridine

Downstream raw materials:

1-tosyl-5-(1-((trimethylsilyl)oxy)cyclobutyl)-2,3-dihydro-1H-pyrrole

C₁₉H₂₅NO₆S

C₁₉H₂₅NO₆S