Technology Process of 4α-(2,4,6-trimethoxyphenyl)epicatechin
There total 7 articles about 4α-(2,4,6-trimethoxyphenyl)epicatechin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
20percent Pd(OH)2/C;
In
methanol; ethyl acetate;
for 3h;
under 750.075 Torr;
DOI:10.1021/jo001462y
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 45 percent / t-BuLi / tetrahydrofuran; pentane / 4 h / -78 °C
2: 86 percent / n-Bu3SnH; CF3COOH / CH2Cl2 / 0.17 h / 20 °C
3: H2 / 20percent Pd(OH)2/C / methanol; ethyl acetate / 3 h / 750.08 Torr
With
hydrogen; tert.-butyl lithium; tri-n-butyl-tin hydride; trifluoroacetic acid;
20percent Pd(OH)2/C;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; pentane;
DOI:10.1021/jo001462y
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 74 percent / NaH / dimethylformamide / 20 °C
2: 47 percent / DDQ / tetrahydrofuran; H2O / 20 °C
3: 66 percent / 4 Angstroem MS; NMMO; tetra-n-propylammonium perruthenate / CH2Cl2 / 20 °C
4: 45 percent / t-BuLi / tetrahydrofuran; pentane / 4 h / -78 °C
5: 86 percent / n-Bu3SnH; CF3COOH / CH2Cl2 / 0.17 h / 20 °C
6: H2 / 20percent Pd(OH)2/C / methanol; ethyl acetate / 3 h / 750.08 Torr
With
tetrapropylammonium perruthennate; 4 Angstroem MS; hydrogen; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hydride; 4-methylmorpholine N-oxide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
20percent Pd(OH)2/C;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; pentane;
DOI:10.1021/jo001462y
