(2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine

Base Information

Chemical Name:(2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine
CAS No.:1269429-24-4
Molecular Formula:C₂₄H₃₄BrNOSi
Molecular Weight:460.53
Hs Code.:

Synonyms:(2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine

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Chemical Property of (2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine

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Technology Process of (2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine

There total 5 articles about (2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₂BrNOSi

: 1269429-24-4
(2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine

Guidance literature:: C₂₄H₃₂BrNOSi; With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 1190391-64-0
4-methoxybenzyl {(1R)-1-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pent-4-yn-1-yl}carbamate

: 1269429-24-4
(2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: platinum(II) chloride / toluene / 6 h / 80 °C / Inert atmosphere

4: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

With sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum(II) chloride; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1269429-24-4
(2S,5R)-2-(4-bromobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: platinum(II) chloride / toluene / 6 h / 80 °C / Inert atmosphere

4: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

With sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum(II) chloride; In dichloromethane; N,N-dimethyl-formamide; toluene;