methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate

Base Information

Chemical Name:methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate
CAS No.:1335284-54-2
Molecular Formula:C₁₆H₁₄FNO₃
Molecular Weight:287.29
Hs Code.:

Synonyms:methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate

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Technology Process of methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate

There total 1 articles about methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 500163-54-2
(+/-)-methyl 2-[(2-fluorophenyl)(hydroxy)methyl]prop-2-enoate

: 1335284-54-2
methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tet.2011.07.074

Reference yield: 91.0%

: 1335284-54-2
methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate

: 1335284-63-3
(E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoic acid

Guidance literature:: methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 8h;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2011.07.074

Reference yield:

: 1335284-54-2
methyl (E)-3-(2-fluorophenyl)-2-[(2-formyl-1H-pyrrol-1-yl)methyl]prop-2-enoate

: 1335284-45-1
3-(2-fluorobenzyl)pyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide / tetrahydrofuran; water / 8 h / 20 °C

2: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / -10 °C

3: sodium azide / tetrahydrofuran; water / 0.5 h / -10 - 20 °C

4: toluene / 0.5 h / 65 °C

5: dmap; formic acid / dichloromethane / 20 °C

With 4-methyl-morpholine; dmap; formic acid; sodium azide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene; 4: Curtius rearrangement;
DOI:10.1016/j.tet.2011.07.074