Technology Process of methyl 4-[(5,6,7,7a,8,9,10,11-octahydro-4H-2-benzo[ef]heptalenyl)carboxamido]benzoate
There total 12 articles about methyl 4-[(5,6,7,7a,8,9,10,11-octahydro-4H-2-benzo[ef]heptalenyl)carboxamido]benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; dmap;
In
benzene;
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: sodium hydride / benzene; mineral oil / 0.25 h / 0 °C
1.2: 20 °C / Reflux
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h
3.1: diisobutylaluminium hydride / hexane; toluene / 1 h / -78 - 20 °C
4.1: sodium hydride / benzene; mineral oil / 0.17 h / 0 °C
4.2: 20 - 70 °C
5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h
6.1: sodium hydroxide / methanol; water / 3 h / 20 °C
7.1: polyphosphoric acid / 4 h / 110 °C
8.1: trifluoroacetic acid; triethylsilane / 60 °C
9.1: aluminum (III) chloride
10.1: sodium hydroxide; bromine / water
11.1: thionyl chloride / benzene / 4 h / Reflux
12.1: dmap; pyridine / benzene / 15 h / 20 °C
With
pyridine; triethylsilane; dmap; aluminum (III) chloride; thionyl chloride; palladium 10% on activated carbon; hydrogen; bromine; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; sodium hydroxide;
In
methanol; hexane; water; ethyl acetate; toluene; mineral oil; benzene;
DOI:10.1016/j.bmc.2013.04.053
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h
2.1: diisobutylaluminium hydride / hexane; toluene / 1 h / -78 - 20 °C
3.1: sodium hydride / benzene; mineral oil / 0.17 h / 0 °C
3.2: 20 - 70 °C
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h
5.1: sodium hydroxide / methanol; water / 3 h / 20 °C
6.1: polyphosphoric acid / 4 h / 110 °C
7.1: trifluoroacetic acid; triethylsilane / 60 °C
8.1: aluminum (III) chloride
9.1: sodium hydroxide; bromine / water
10.1: thionyl chloride / benzene / 4 h / Reflux
11.1: dmap; pyridine / benzene / 15 h / 20 °C
With
pyridine; triethylsilane; dmap; aluminum (III) chloride; thionyl chloride; palladium 10% on activated carbon; hydrogen; bromine; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; sodium hydroxide;
In
methanol; hexane; water; ethyl acetate; toluene; mineral oil; benzene;
DOI:10.1016/j.bmc.2013.04.053
