6-(4-CHLOROPHENYL)-4-(4-METHYLPHENYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONE

Base Information

• Chemical Name: 6-(4-CHLOROPHENYL)-4-(4-METHYLPHENYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONE
• CAS No.: 70596-87-1
• Molecular Formula: C₁₇H₁₅ClN₂O
• Molecular Weight: 298.772
• Mol file: 70596-87-1.mol

Synonyms:6-(4-chloro-phenyl)-4-p-tolyl-4,5-dihydro-2H-pyridazin-3-one

Chemical Property of 6-(4-CHLOROPHENYL)-4-(4-METHYLPHENYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONE

Chemical Property:

• Melting Point: 177-178 °C(Solv: benzene (71-43-2))
• PKA: 13.17±0.60(Predicted)
• Density: 1.26±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

6-(4-Chlorophenyl)-4-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 6-(4-CHLOROPHENYL)-4-(4-METHYLPHENYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONE

There total 2 articles about 6-(4-CHLOROPHENYL)-4-(4-METHYLPHENYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-(4-chloro-phenyl)-4-oxo-2-p-tolyl-butyric acid methyl ester (344280-20-2) → 6-(4-chloro-phenyl)-4-p-tolyl-4,5-dihydro-2H-pyridazin-3-one (70596-87-1)

Guidance literature:

With hydrazine hydrate; In diethylene glycol; for 4h; Heating;

DOI:10.1081/SCC-100103250

Reference yield:

4-(4-chlorophenyl)-4-oxo-2-(4-tolyl)butanenitrile (101602-33-9) → 6-(4-chloro-phenyl)-4-p-tolyl-4,5-dihydro-2H-pyridazin-3-one (70596-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / Heating

2: 68 percent / N₂H₄*H₂O / bis-(2-hydroxy-ethyl) ether / 4 h / Heating

With sulfuric acid; hydrazine hydrate; In diethylene glycol;

DOI:10.1081/SCC-100103250

Reference yield: 80.0%

6-(4-chloro-phenyl)-4-p-tolyl-4,5-dihydro-2H-pyridazin-3-one (70596-87-1) → 6-(4-chloro-phenyl)-4-p-tolyl-2H-pyridazin-3-one

Guidance literature:

With selenium(IV) oxide; for 0.05h; microwave irradiation;

DOI:10.1081/SCC-100103250

upstream raw materials:

4-(4-chloro-phenyl)-4-oxo-2-p-tolyl-butyric acid methyl ester

4-(4-chlorophenyl)-4-oxo-2-(4-tolyl)butanenitrile

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