(3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol

Base Information

Chemical Name:(3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol
CAS No.:643001-85-8
Molecular Formula:C₁₉H₂₁NO₃
Molecular Weight:311.381
Hs Code.:

Synonyms:(3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol

Chemical Property:

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Technology Process of (3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol

There total 4 articles about (3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 643001-84-7
methyl [(2S,4R)-1-(1,1'-biphenyl-4-ylcarbonyl)-4-hydroxy-pyrrolidin-2-yl]acetate

: 643001-85-8
(3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield:

: 643001-83-6
[(2S,4R)-1-(1,1'-biphenyl-4-ylcarbonyl)-4-hydroxypyrrolidin-2-yl]acetic acid

: 643001-85-8
(3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; hexane; toluene / 3 h

2: lithium borohydride / tetrahydrofuran / 12 h / 0 - 20 °C

With lithium borohydride; In tetrahydrofuran; methanol; hexane; toluene;

Reference yield:

: 32968-78-8,441067-49-8
(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid hydrochloride

: 643001-85-8
(3R,5R)-1-(1,1'-biphenyl-4-ylcarbonyl)-5-(2-hydroxyethyl)-pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; water / 18 h / 0 - 20 °C

2: methanol; hexane; toluene / 3 h

3: lithium borohydride / tetrahydrofuran / 12 h / 0 - 20 °C

With lithium borohydride; triethylamine; In tetrahydrofuran; methanol; hexane; water; toluene;