6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline

Base Information

Chemical Name:6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline
CAS No.:182217-65-8
Molecular Formula:C₁₉H₁₇N₃O₄
Molecular Weight:351.362
Hs Code.:

Synonyms:6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline

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Chemical Property of 6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline

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Technology Process of 6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline

There total 8 articles about 6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 199456-65-0
4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-(dimethyl-hydrazonomethyl)-ethyl]-benzoic acid methyl ester

: 4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-acetyl]-benzoic acid methyl ester

: 182217-65-8
6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline

Guidance literature:: With phosphate buffer; copper dichloride; In tetrahydrofuran; at 0 ℃; for 1h; Yield given;
DOI:10.1016/S0968-0896(97)00120-X

Reference yield:

: 58677-07-9
N-[6-(bromomethyl)-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide

: 182217-65-8
6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, HMPA, -78 deg C, 6 h

2: 86 percent / aq. LiOH / tetrahydrofuran; methanol / 48 h / 25 °C

3: 96 percent / dimethylformamide; diethyl ether / 24 h / 25 °C

4: 55 percent / aq. CuCl₂, phosphate buffer / tetrahydrofuran / 1 h / 0 °C

With lithium hydroxide; phosphate buffer; copper dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00120-X

Reference yield:

: 106918-32-5
4-carbomethoxyphenylacetaldehyde

: 182217-65-8
6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / MgSO₄ / diethyl ether / 2 h / 25 °C

2: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, HMPA, -78 deg C, 6 h

3: 86 percent / aq. LiOH / tetrahydrofuran; methanol / 48 h / 25 °C

4: 96 percent / dimethylformamide; diethyl ether / 24 h / 25 °C

5: 55 percent / aq. CuCl₂, phosphate buffer / tetrahydrofuran / 1 h / 0 °C

With lithium hydroxide; phosphate buffer; magnesium sulfate; copper dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00120-X