3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone

Base Information

Chemical Name:3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone
CAS No.:1432051-34-7
Molecular Formula:C₁₆H₁₃ClFNO₂
Molecular Weight:305.736
Hs Code.:

Synonyms:3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone

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Chemical Property of 3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone

Chemical Property:

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Technology Process of 3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone

There total 7 articles about 3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432051-20-1
3-(3-chloro-4-fluorophenyl)-3-[hydroxy(pyridin-2-yl)methyl]-cyclobutanone

: 1432051-34-7
3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone

Guidance literature:: With Chiralpak AD-H column; Resolution of racemate;

Reference yield:

: 1432051-09-6
[2-(3-chloro-4-fluorophenyl)-5,8-dioxaspiro[3.4]oct-2-yl](pyridin-2-yl)-methanol

: 1432051-34-7
3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; acetone / 20 °C

2: Chiralpak AD-H column / Resolution of racemate

With hydrogenchloride; In water; acetone;

Reference yield:

: 1432051-10-9
1-(3-chloro-4-fluorophenyl)-3-hydroxycyclobutanecarbonitrile

: 1432051-34-7
3-(3-chloro-4-fluorophenyl)-3-[(S)-hydroxy(pyridin-2-yl)methyl]-cyclobutanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: Dess-Martin periodane / dichloromethane / 20 °C

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 1 h / -75 °C

3.2: 2 h / -75 - 0 °C

4.1: methanol; sodium tetrahydroborate / dichloromethane

5.1: hydrogenchloride / water; acetone / 20 °C

6.1: Chiralpak AD-H column / Resolution of racemate

With hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; Dess-Martin periodane; In diethyl ether; hexane; dichloromethane; water; acetone;