(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester

Base Information

Chemical Name:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester
CAS No.:143924-97-4
Molecular Formula:C₃₀H₄₀F₃IO₆
Molecular Weight:680.544
Hs Code.:

(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester

Synonyms:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester

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Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester

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Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester

There total 13 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130514-54-4
(1'S,3R,5S,6S)-(+)-6-<1'-(t-butyldiphenylsilyloxymethyl)propyl>-3,5-dimethyltetrahydropyran-2-one

: 143924-97-4
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) n-BuLi / 1.) THF, hexane, -75 deg C, 1 h, 2.) -75 deg C, 0.5 h

2: 83 mg / Amberlite IR 120 (H⁺) / 1 h

3: hydrogen / Lindlar catalyst / hexane; ethyl acetate / 5 h

4: PPTS / CH₂Cl₂ / 0.2 h

5: 97 percent / NaH / tetrahydrofuran; paraffin / Ambient temperature

6: 91 percent / LiI, BF₃*OEt₂ / tetrahydrofuran / 1 h / -50 °C

7: 36 percent / iodine, (diacetoxyiodo)benzene / cyclohexane / 1.5 h / 18 °C / Irradiation

8: 2.5 mg / tetra-n-butylammonium fluoride / tetrahydrofuran

9: pyridine / CCl₄ / Ambient temperature

With pyridine; n-butyllithium; [bis(acetoxy)iodo]benzene; Amberlite IR 120 (H⁺); boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; iodine; pyridinium p-toluenesulfonate; sodium hydride; lithium iodide; Lindlar's catalyst; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; cyclohexane; ethyl acetate; paraffin;
DOI:10.1021/jo00048a009

Reference yield:

: 143924-91-8
Toluene-4-sulfonic acid (S)-8-{(3R,5S,6S)-6-[(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-yl}-2-methyl-2,5-bis-trimethylsilanyloxy-oct-7-ynyl ester

: 143924-97-4
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / Lindlar catalyst / hexane; ethyl acetate / 5 h

2: PPTS / CH₂Cl₂ / 0.2 h

3: 97 percent / NaH / tetrahydrofuran; paraffin / Ambient temperature

4: 91 percent / LiI, BF₃*OEt₂ / tetrahydrofuran / 1 h / -50 °C

5: 36 percent / iodine, (diacetoxyiodo)benzene / cyclohexane / 1.5 h / 18 °C / Irradiation

6: 2.5 mg / tetra-n-butylammonium fluoride / tetrahydrofuran

7: pyridine / CCl₄ / Ambient temperature

With pyridine; [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; iodine; pyridinium p-toluenesulfonate; sodium hydride; lithium iodide; Lindlar's catalyst; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; cyclohexane; ethyl acetate; paraffin;
DOI:10.1021/jo00048a009

Reference yield:

: 130284-43-4,137103-96-9,138290-69-4,144015-89-4,144015-90-7
Toluene-4-sulfonic acid (S)-2-methyl-2,5-bis-trimethylsilanyloxy-oct-7-ynyl ester

: 143924-97-4
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-((2S,5S,7S,9S,10S,12R)-2-iodomethyl-2,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-9-yl)-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) n-BuLi / 1.) THF, hexane, -75 deg C, 1 h, 2.) -75 deg C, 0.5 h

2: 83 mg / Amberlite IR 120 (H⁺) / 1 h

3: hydrogen / Lindlar catalyst / hexane; ethyl acetate / 5 h

4: PPTS / CH₂Cl₂ / 0.2 h

5: 97 percent / NaH / tetrahydrofuran; paraffin / Ambient temperature

6: 91 percent / LiI, BF₃*OEt₂ / tetrahydrofuran / 1 h / -50 °C

7: 36 percent / iodine, (diacetoxyiodo)benzene / cyclohexane / 1.5 h / 18 °C / Irradiation

8: 2.5 mg / tetra-n-butylammonium fluoride / tetrahydrofuran

9: pyridine / CCl₄ / Ambient temperature

With pyridine; n-butyllithium; [bis(acetoxy)iodo]benzene; Amberlite IR 120 (H⁺); boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; iodine; pyridinium p-toluenesulfonate; sodium hydride; lithium iodide; Lindlar's catalyst; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; cyclohexane; ethyl acetate; paraffin;
DOI:10.1021/jo00048a009