5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone

Base Information

Chemical Name:5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone
CAS No.:1140972-23-1
Molecular Formula:C₂₇H₂₉NO₅S
Molecular Weight:479.597
Hs Code.:

Synonyms:5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone

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Chemical Property of 5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone

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Technology Process of 5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone

There total 6 articles about 5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 910805-49-1
phenyl N-benzyl-2-amino-4,6-O-benzylidene-2,3-N,O-carbonyl-2-deoxy-1-thio-β-D-glucopyranoside

: 910805-51-5
phenyl N-benzyl-2-amino-6-O-benzyl-2,3-N,O-carbonyl-2-deoxy-1-thio-α-D-glucopyranoside

: 1140972-23-1
5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 6h;
DOI:10.1002/ejoc.200801140

Reference yield: 49.0%

: 910805-49-1
phenyl N-benzyl-2-amino-4,6-O-benzylidene-2,3-N,O-carbonyl-2-deoxy-1-thio-β-D-glucopyranoside

: 910805-50-4
phenyl N-benzyl-2-amino-6-O-benzyl-2,3-N,O-carbonyl-2-deoxy-1-thio-β-D-glucopyranoside

: 910805-51-5
phenyl N-benzyl-2-amino-6-O-benzyl-2,3-N,O-carbonyl-2-deoxy-1-thio-α-D-glucopyranoside

: 1140972-23-1
5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 0.5h; diastereoselective reaction;
DOI:10.1002/ejoc.200801140

Reference yield:

: phenyl N-(2,2,2-trichloroethoxy)carbonyl-2-amino-4,6-O-benzylidene-2-deoxy-1-thio-β-D-glucopyranoside

: 910805-51-5
phenyl N-benzyl-2-amino-6-O-benzyl-2,3-N,O-carbonyl-2-deoxy-1-thio-α-D-glucopyranoside

: 1140972-23-1
5-[(1R,2R)-1,2-dihydroxy-3-(phenylmethoxy)propyl]-3-(phenylmethyl)-4-[(phenylthio)methyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 6 h / 0 °C

2.2: Saturated solution

With triethylsilane; boron trifluoride diethyl etherate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.09.059