2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Base Information

• Chemical Name: 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride
• CAS No.: 1243257-37-5
• Molecular Formula: C₃₇H₃₃Cl₃N₂O₆*ClH
• Molecular Weight: 744.499
• Mol file: 1243257-37-5.mol

Synonyms:2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Chemical Property of 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

There total 5 articles about 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

C18H19Cl2NO3 (1160554-11-9) + 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride (20357-37-3) → 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride (1243257-37-5)

Guidance literature:

C₁₈H₁₉Cl₂NO₃; 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;

With hydrogenchloride; In diethyl ether;

DOI:10.1002/cjoc.201200196

Reference yield:

1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one (119851-28-4) → 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride (1243257-37-5)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(ll) bromide / ethanol / 6 h / Reflux

2: 1-methyl-pyrrolidin-2-one / 2 h / 60 °C

3: formic acid / 18 h / 180 °C

4: triethylamine / tetrahydrofuran / 6 h / 20 °C

With formic acid; triethylamine; copper(ll) bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; 3: Leuckart-Wallach reaction;

DOI:10.1002/cjoc.201200196

Reference yield:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride (1243257-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 3 h / 0 °C

2: triethylamine / tetrahydrofuran / 6 h / 20 °C

With oxalyl dichloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/cjoc.201200196

upstream raw materials:

1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

2-bromo-1-(2-chloro-4-(4-chlorophenoxy)phenyl)ethanone

C₁₈H₁₉Cl₂NO₃

1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride

Refernces