1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea

Base Information

• Chemical Name: 1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea
• CAS No.: 110193-23-2
• Molecular Formula: C₂₃H₂₈N₄O₃
• Molecular Weight: 408.5

Synonyms:1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea

Chemical Property of 1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea

Chemical Property:

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Technology Process of 1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea

There total 5 articles about 1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1,1-Diethyl-3-{(R)-2-hydroxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-ethyl}-3-methyl-urea (110193-15-2) → 1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea (110193-23-2)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00394a026

Reference yield:

2-chloromethyl-1-methyl-1H-benzimidazole (4760-35-4) → 1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea (110193-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / cesium carbonate / acetone / 48 h / Heating

2: 30 percent / pyridinium chlorochromate / CH₂Cl₂ / Ambient temperature

With caesium carbonate; pyridinium chlorochromate; In dichloromethane; acetone;

DOI:10.1021/jm00394a026

Reference yield:

phenylephrine hydrochloride (61-76-7,827-62-3) → 1,1-Diethyl-3-methyl-3-{2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-2-oxo-ethyl}-urea (110193-23-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / triethylamine / tetrahydrofuran / 1 h

2: 64 percent / cesium carbonate / acetone / 48 h / Heating

3: 30 percent / pyridinium chlorochromate / CH₂Cl₂ / Ambient temperature

With caesium carbonate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1021/jm00394a026

upstream raw materials:

1,1-Diethyl-3-{(R)-2-hydroxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-ethyl}-3-methyl-urea

2-chloromethyl-1-methyl-1H-benzimidazole

phenylephrine hydrochloride

N,N-diethylcarbamyl chloride

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