(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine

Base Information

Chemical Name:(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine
CAS No.:911422-95-2
Molecular Formula:C₂₇H₃₈N₂O
Molecular Weight:406.612
Hs Code.:

Synonyms:(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine

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Chemical Property of (1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine

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Technology Process of (1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine

There total 15 articles about (1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,4R,5S)-5-(3-Isopropoxy-phenyl)-4-methyl-2-(3-phenyl-propyl)-2-aza-bicyclo[3.3.1]nonan-7-one oxime

: 911422-95-2
(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine

Guidance literature:: With sodium; isopropyl alcohol; In toluene; Heating;
DOI:10.1021/jm020084h

Reference yield:

: 911422-94-1
2-[(1S,4R,5S,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-1H-isoindole-1,3(2H)-dione

: 911422-95-2
(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine

Guidance literature:: With hydrazine; In ethanol; for 4.5h; Heating;
DOI:10.1021/jm060459p

Reference yield:

: (+)-(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-amine

: 911422-95-2
(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 64 percent / toluene / Heating

2.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 4 h / Heating

2.2: methanol / Heating

3.1: 1.07 g / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

4.1: hydrazine / ethanol / 4.5 h / Heating

With carbonochloridic acid 1-chloro-ethyl ester; sodium tris(acetoxy)borohydride; hydrazine; In ethanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jm060459p