4,4-difluoro-cyclohexanecarboxylic acid (1-phenyl-but-3-enyl)-amide

Base Information

• Chemical Name: 4,4-difluoro-cyclohexanecarboxylic acid (1-phenyl-but-3-enyl)-amide
• CAS No.: 1000681-06-0
• Molecular Formula: C₁₇H₂₁F₂NO
• Molecular Weight: 293.357
• Mol file: 1000681-06-0.mol

Synonyms:4,4-difluoro-cyclohexanecarboxylic acid (1-phenyl-but-3-enyl)-amide

Chemical Property of 4,4-difluoro-cyclohexanecarboxylic acid (1-phenyl-but-3-enyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4,4-difluoro-cyclohexanecarboxylic acid (1-phenyl-but-3-enyl)-amide

There total 1 articles about 4,4-difluoro-cyclohexanecarboxylic acid (1-phenyl-but-3-enyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4-difluoro-cyclohexanecarboxylic acid benzylideneamide + diisopropyl allylboronate (51851-79-7) → C17H21F2NO + 4,4-difluoro-cyclohexanecarboxylic acid (1-phenyl-but-3-enyl)-amide (1000681-06-0)

Guidance literature:

With 3 A molecular sieve; (R)-3,3'-Ph₂-BINOL; In toluene; at 20 ℃; for 24h; Title compound not separated from byproducts.;

DOI:10.1021/ja075204v

Reference yield:

4,4-difluoro-cyclohexanecarboxylic acid (1-phenyl-but-3-enyl)-amide (1000681-06-0) → 4,4-difluorocyclohexanecarboxylic acid (3-oxo-1-phenyl-propyl)-amide (376348-78-6)

Guidance literature:

With sodium peroxide; ruthenium trichloride; In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/ja075204v

upstream raw materials:

diisopropyl allylboronate

Downstream raw materials:

4,4-difluorocyclohexanecarboxylic acid (3-oxo-1-phenyl-propyl)-amide