(2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

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Chemical Name:(2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
CAS No.:1330642-14-2
Molecular Formula:C₄₈H₇₆N₄O₁₀
Molecular Weight:869.152
Hs Code.:

Synonyms:(2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

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Chemical Property of (2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

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Technology Process of (2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

There total 3 articles about (2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1330642-25-5
(2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetraazacyclododecane

: 1330642-14-2
(2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;
DOI:10.1021/ic2010997

Reference yield:

: 2620-09-9
N,N'-bis(chloroacetyl)ethylenediamine

: 1330642-14-2
(2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / acetonitrile / 24 h / Reflux

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3.5 h / 0 - 80 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

With sodium carbonate; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ic2010997

Reference yield:

: 109582-31-2,136597-79-0,139951-77-2,142071-04-3
(2S,3S)-1,4-bis(phenylmethoxy)-2,3-diaminobutane

: 1330642-14-2
(2S,3S)-2,3-bis(benzyloxymethyl)-1,4,7,10-tetra(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / acetonitrile / 24 h / Reflux

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3.5 h / 0 - 80 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

With sodium carbonate; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ic2010997