2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt

Base Information

Chemical Name:2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt
CAS No.:1402390-35-5
Molecular Formula:C₂HF₃O₂*C₂₄H₂₃N₇O
Molecular Weight:539.517
Hs Code.:

Synonyms:2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt

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Chemical Property of 2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt

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Technology Process of 2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt

There total 7 articles about 2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402390-59-3
2-methyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]propanenitrile

: 1402390-50-4
5-bromo-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

: 76-05-1
trifluoroacetic acid

: 1402390-35-5
2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt

Guidance literature:: 2-methyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]propanenitrile; 5-bromo-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 153034-86-7
2-chloro-4-iodopyridine

: 1402390-35-5
2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / toluene; tetrahydrofuran / 0 - 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With potassium acetate; sodium hexamethyldisilazane; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; toluene;

Reference yield:

: 1217486-73-1
2-(4-iodo-2-pyridyl)-2-methyl-propanenitrile

: 1402390-35-5
2-[4-[5-amino-6-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-yl]-2-pyridyl]-2-methylpropanenitrile trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With potassium acetate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;