N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide

Base Information

Chemical Name:N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide
CAS No.:1295567-61-1
Molecular Formula:C₂₄H₂₄F₂IN₃O₅S₂
Molecular Weight:663.505
Hs Code.:

Synonyms:N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide

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Chemical Property of N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide

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Technology Process of N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide

There total 10 articles about N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10147-37-2
Isopropylsulfonyl chloride

: 1295567-74-6
N-{2-(3-aminophenoxy)-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl}cyclopropanesulfonamide

: 1295567-61-1
N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 16h;

Reference yield:

: 765962-75-2
3,5-difluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline

: 1295567-61-1
N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: sodium dithionite / tetrahydrofuran / 1 h / 50 °C

3.1: pyridine / 16 h

4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

4.2: 0 °C / pH 10

5.1: pyridine / 16 h / 20 °C

With pyridine; sodium dithionite; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295567-61-1
N-(4-fluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(isopropylsulfonyl)amino]phenoxy}phenyl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 0 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium dithionite / tetrahydrofuran / 1 h / 50 °C

4.1: pyridine / 16 h

5.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

5.2: 0 °C / pH 10

6.1: pyridine / 16 h / 20 °C

With pyridine; sodium dithionite; caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;