(S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate

Base Information

• Chemical Name: (S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate
• CAS No.: 280122-36-3
• Molecular Formula: C₁₈H₂₇NO₇S
• Molecular Weight: 401.481
• Mol file: 280122-36-3.mol

Synonyms:(S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate

Chemical Property of (S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate

There total 3 articles about (S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

p-toluenesulfonyl chloride (98-59-9) + (S)-N-(carboxymethyl)-N-[2-hydroxyethyl]alanine, diethyl ester (280122-34-1) → (S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate (280122-36-3)

Guidance literature:

With pyridine; at -5 ℃;

DOI:10.1016/S0040-4020(00)00103-4

Reference yield:

(S)-N-(carboxymethyl)alanine, diethyl ester (92232-99-0) → (S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate (280122-36-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 1,2,2,6,6-pentamethylpiperidine / toluene / 96 h / Heating

2: 100 percent / H₂ / Pd(OH)2/C / ethyl acetate / 3 h / 760 Torr

3: 93 percent / pyridine / -5 °C

With pyridine; 1,2,2,6,6-pentamethylpiperidine; hydrogen; palladium dihydroxide; In ethyl acetate; toluene; 1: Alkylation / 2: Catalytic hydrogenation / 3: Tosylation;

DOI:10.1016/S0040-4020(00)00103-4

Reference yield:

(S)-N-[2-(benzyloxy)ethyl]-N-(carboxymethyl)alanine, diethyl ester (280122-32-9) → (S)-N-(carboxymethyl)-N-(2-hydroxyethyl)alanine, diethyl ester, p-toluenesulfonate (280122-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd(OH)2/C / ethyl acetate / 3 h / 760 Torr

2: 93 percent / pyridine / -5 °C

With pyridine; hydrogen; palladium dihydroxide; In ethyl acetate; 1: Catalytic hydrogenation / 2: Tosylation;

DOI:10.1016/S0040-4020(00)00103-4

upstream raw materials:

p-toluenesulfonyl chloride

(S)-N-(carboxymethyl)-N-[2-hydroxyethyl]alanine, diethyl ester

(S)-N-(carboxymethyl)alanine, diethyl ester

(S)-N-[2-(benzyloxy)ethyl]-N-(carboxymethyl)alanine, diethyl ester