[1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester
CAS No.:1027416-60-9
Molecular Formula:C₂₁H₂₇NO₅
Molecular Weight:373.449
Hs Code.:

[1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of [1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

There total 2 articles about [1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6346-05-0
3-benzyloxy-4-methoxybenzaldehyde

: 1027416-60-9
[1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / KHMDS / tetrahydrofuran

2: K₂OsO₂(OH)4; (DHQD)2PHAL / propan-1-ol; H₂O

With potassium dioxotetrahydroxoosmate(VI); potassium hexamethylsilazane; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; propan-1-ol; water; 1: Wittig olefination / 2: Sharpless asymmetric amino-hydroxylation;
DOI:10.1021/ja011943e

Reference yield:

: 68360-39-4
2-(3-benzyloxy-4-methoxyphenyl)ethylene

: 73210-14-7
N-chloro-N-sodio-tert-butylcarbamate

: 1027416-60-9
[1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With potassium dioxotetrahydroxoosmate(VI); 1,4-bis(9-O-dihydroquinidine)phthalazine; In propan-1-ol; water;
DOI:10.1021/ja011943e

Reference yield:

: 1027416-60-9
[1-(3-benzyloxy-4-methoxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

: 391213-82-4
(8S,11R,14R)-11-(4-Fluoro-3-nitro-benzyl)-5,18-dimethoxy-10,13-dioxo-14-(2,2,2-trifluoro-acetylamino)-2-oxa-9,12-diaza-tricyclo[13.3.1.1^3,7]icosa-1⁽¹⁸⁾,3⁽²⁰⁾,4,6,15⁽¹⁹⁾,16-hexaene-8-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 9 steps

1: TEMPO; NaOCl; KBr / acetone; H₂O

2: 100 percent / H₂ / Pd/C / ethanol / 760.05 Torr

3: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 1-hydroxy-7-azabenzotriazole / tetrahydrofuran / 0 - 20 °C

4: TFA; DMS / CH₂Cl₂ / 0 °C

5: 2,6-lutidine / CH₂Cl₂ / 0 °C

6: 80 percent / Cu(OAc)2; pyridine; O₂ / CH₂Cl₂ / 20 °C

7: 99 percent / LiOH / methanol; H₂O / 0 °C

8: TFA; DMS / CH₂Cl₂ / 0 °C

9: HATU; HOAt / CH₂Cl₂; dimethylformamide / 0 - 20 °C

With pyridine; 2,6-dimethylpyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; lithium hydroxide; sodium hypochlorite; 1-hydroxy-7-aza-benzotriazole; copper diacetate; 2,3-dimercapto-succinic acid; hydrogen; oxygen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja011943e