2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate

Base Information

Chemical Name:2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate
CAS No.:1255926-36-3
Molecular Formula:C₂₈H₃₂N₂O₇S
Molecular Weight:540.637
Hs Code.:

Synonyms:2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate

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Chemical Property of 2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate

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Technology Process of 2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate

There total 4 articles about 2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

: 1255926-35-2
5-(5-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}-1-benzofuran-2-yl)-N,N-dimethylpyridin-2-amine

: 98-59-9
p-toluenesulfonyl chloride

: 1255926-36-3
2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate

Guidance literature:: With pyridine; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2010.08.016

Reference yield:

: 1255926-34-1
2-(2-(2-(2-(6-(dimethylamino)pyridin-3-yl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

: 1255926-36-3
2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / 1,2-dimethoxyethane / 1 h / 20 °C / Cooling with acetone-dry ice

2: pyridine / 3 h / 20 °C

With pyridine; diethylamino-sulfur trifluoride; In 1,2-dimethoxyethane;

Reference yield:

: 1255926-32-9
5-(5-methoxy-1-benzofuran-2-yl)-N,N-dimethylpyridin-2-amine

: 1255926-36-3
2-{2-[2-({2-[6-(dimethylamino)pyridin-3-yl]-1-benzofuran-5-yl}oxy)ethoxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

3: diethylamino-sulfur trifluoride / 1,2-dimethoxyethane / 1 h / 20 °C / Cooling with acetone-dry ice

4: pyridine / 3 h / 20 °C

With pyridine; diethylamino-sulfur trifluoride; boron tribromide; potassium carbonate; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;