1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

Base Information

Chemical Name:1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea
CAS No.:1344738-27-7
Molecular Formula:C₄₁H₄₄ClN₇O₅S₂
Molecular Weight:814.429
Hs Code.:

1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

Synonyms:1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

Suppliers and Price of 1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

There total 13 articles about 1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₃N₃O₄S₂

: 1344738-27-7
1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 16 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With ammonia; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/jm200677b

Reference yield:

: 876299-32-0
4,4-dimethyl-5-(methylthio)-3-oxopentanenitrile

: 1344738-27-7
1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / ethanol; water / 6 h / Reflux; Inert atmosphere

2: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

4: dichloromethane / 16 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b

Reference yield:

: 876299-31-9
methyl 2,2-dimethyl-3-(methylthio)propanoate

: 1344738-27-7
1-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)-3-(3-[1,1-dimethyl-2-(methylthio)ethyl]-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 75 °C / Inert atmosphere

2: hydrogenchloride / ethanol; water / 6 h / Reflux; Inert atmosphere

3: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

5: dichloromethane / 16 h / 20 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; boron tribromide; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200677b