(+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt

Base Information

Chemical Name:(+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt
CAS No.:126264-13-9
Molecular Formula:C₇H₆O₂*C₁₁H₂₁NO
Molecular Weight:305.417
Hs Code.:

Synonyms:(+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt

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Chemical Property of (+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt

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Technology Process of (+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt

There total 4 articles about (+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.6%

: 126264-12-8
(+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol

: 65-85-0,8013-63-6
benzoic acid

: 126264-13-9
(+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt

Guidance literature:: In diethyl ether;
DOI:10.1248/cpb.37.1524

Reference yield:

: 86777-96-0
ethyl ((1R,3R,5S)-2-methylidene-6,6-dimethylbicyclo[3.1.1]-hept-3-yl)acetate

: 126264-13-9
(+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ozonized oxygen, 2.) dimethyl sulfide, / 1.) methanol, -78 deg C, 2.) from - 10 deg C to room temperature over 3 h,

2: 87.8 percent / pyridine / ethanol / 3 h / Heating

3: 79.5 percent / sodium metal / propan-1-ol / 1 h / Heating

4: 39.6 percent / diethyl ether

With pyridine; ozone-containing oxygen; dimethylsulfide; sodium; In propan-1-ol; diethyl ether; ethanol;
DOI:10.1248/cpb.37.1524

Reference yield:

: 126264-10-6
ethyl ((1R,3R,5S)-2-oxo-6,6-dimethylbicyclo<3.1.1>hept-3-yl)acetate

: 126264-13-9
(+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo<3.1.1>hept-3-yl)-ethanol-benzoic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: 87.8 percent / pyridine / ethanol / 3 h / Heating

2: 79.5 percent / sodium metal / propan-1-ol / 1 h / Heating

3: 39.6 percent / diethyl ether

With pyridine; sodium; In propan-1-ol; diethyl ether; ethanol;
DOI:10.1248/cpb.37.1524