(benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine

Base Information

• Chemical Name: (benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine
• CAS No.: 145471-95-0
• Molecular Formula: C₂₄H₃₅N₂O₄P
• Molecular Weight: 446.527
• Mol file: 145471-95-0.mol

Synonyms:(benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine

Chemical Property of (benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine

There total 4 articles about (benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

3-[(N-benzyloxycarbonyl)amino]propanol (34637-22-4) + N,N-diisopropylphosphoramide dichloride (921-26-6) → Dibenzyl N,N-diisopropylphosphoramidite (108549-23-1) + (benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine (145471-95-0) + Bis<3-(benzyloxycarbonylamino)propyl> di-N-isopropylphosphoramidite

Guidance literature:

With N-ethyl-N,N-diisopropylamine; benzyl alcohol; Yield given. Multistep reaction; 1) THF, 25 deg C, 18 h, 2) THF, 25 deg C, 4 h;

DOI:10.1016/S0008-6215(00)90513-5

Reference yield: 33.0%

N,N-diisopropylphosphoramide dichloride (921-26-6) + benzyl alcohol (100-51-6,185532-71-2) → Dibenzyl N,N-diisopropylphosphoramidite (108549-23-1) + (benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine (145471-95-0) + Bis<3-(benzyloxycarbonylamino)propyl> di-N-isopropylphosphoramidite

Guidance literature:

With 3-[(N-benzyloxycarbonyl)amino]propanol; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1) THF, 25 deg C, 18 h, 2) THF, 25 deg C, 4 h;

DOI:10.1016/S0008-6215(00)90513-5

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (benzyloxy)<(3-(N-carbobenzoxyamino)propyl)oxy>(diisopropylamino)phosphine (145471-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 2 M NaOH / toluene / 48 h / 25 °C

2: 33 percent / 1) diisopropylethylamine, 2) benzyl alcohol / 1) THF, 25 deg C, 18 h, 2) THF, 25 deg C, 4 h

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; benzyl alcohol; In toluene;

DOI:10.1016/S0008-6215(00)90513-5

upstream raw materials:

3-[(N-benzyloxycarbonyl)amino]propanol

N,N-diisopropylphosphoramide dichloride

benzyl alcohol

benzyl chloroformate

Downstream raw materials:

Benzyl (1,3,4,5,6-penta-O-allyl-myo-inosityl) 2-O-(N-Cbz-3-aminopropyl)phosphate

{3-[Benzyloxy-((1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxy-cyclohexyloxy)-phosphoryloxy]-propyl}-carbamic acid benzyl ester

1-O-<(Benzyloxy)-3-(benzyloxycarbonylamino)propoxyphosphinyl>-2,3,6-tri-O-benzoyl-4,5-bis-O-(dibenzyloxyphosphinyl)-D-myo-inositol