tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Base Information

Chemical Name:tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane
CAS No.:627075-73-4
Molecular Formula:C₂₇H₃₂O₂Si
Molecular Weight:416.635
Hs Code.:

<i>tert</i>-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Synonyms:tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

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Technology Process of tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

There total 6 articles about tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: (S)-7-Methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-ol

: 627075-73-4
tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1021/ol035559t

Reference yield:

: 630414-65-2
((E)-1-(4-iodofuran-3-yl)-4-methylhex-4-enyloxy)(tert-butyl)diphenylsilane

: 627075-73-4
tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Guidance literature:: With tetrabutylammomium bromide; triethylamine; palladium diacetate; In water; acetonitrile; at 75 ℃;
DOI:10.1021/ol035559t

Reference yield:

: 27799-31-1
4-methyl-trans-4-hexenal

: 627075-73-4
tert-butyl-(7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / n-BuLi / diethyl ether; hexane / 0.33 h / -78 °C

2: 88 percent / Dess-Martin periodinane / CH₂Cl₂ / 0 - 20 °C

3: (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 66 h / -20 °C

4: 98 percent / imidazole; DMAP / CH₂Cl₂ / 20 °C

5: Et₃N; TBAB / Pd(OAc)2 / acetonitrile; H₂O / 75 °C

With 1H-imidazole; dmap; n-butyllithium; tetrabutylammomium bromide; Dess-Martin periodane; triethylamine; (-)-diisopinocamphenylborane chloride; palladium diacetate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetonitrile; 2: Dess-Martin oxidation / 5: Heck reaction;
DOI:10.1021/ol035559t