1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 302934-94-7
• Molecular Formula: C₁₆H₁₉ClN₂O₃
• Molecular Weight: 322.791
• Mol file: 302934-94-7.mol

Synonyms:1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

There total 2 articles about 1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N,N'-Dimethylurea (96-31-1) + ethyl acetoacetate (141-97-9) + 4-chlorobenzaldehyde (104-88-1) → 1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester (302934-94-7)

Guidance literature:

With ammonium cerium (IV) nitrate; In neat (no solvent); at 80 ℃; for 0.0305556h; Microwave irradiation;

DOI:10.1002/jhet.2735

Reference yield: 90.0%

ethyl acetoacetate (141-97-9) + 4-chlorobenzaldehyde (104-88-1) → 1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester (302934-94-7)

Guidance literature:

at 70 ℃; for 20h;

DOI:10.1039/c1gc00009h

Reference yield:

1,3,6-trimethyl-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester (302934-94-7) → C16H18BrClN2O3

Guidance literature:

With bromine; In chloroform; at 0 ℃;

DOI:10.1016/j.bioorg.2019.103128

upstream raw materials:

N,N'-Dimethylurea

ethyl acetoacetate

4-chlorobenzaldehyde