Carbamic acid, [5-(chlorocarbonyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

Chemical Name:Carbamic acid, [5-(chlorocarbonyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)
CAS No.:302964-20-1
Molecular Formula:C9H11 Cl N2 O3 S
Molecular Weight:262.717
Hs Code.:
Mol file:302964-20-1.mol

Synonyms:Carbamic acid, [5-(chlorocarbonyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

Suppliers and Price of Carbamic acid, [5-(chlorocarbonyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
tert-Butyl(5-(chlorocarbonyl)thiazol-2-yl)carbamate 95%
1g
$ 204.00

Alichem
tert-Butyl(5-(chlorocarbonyl)thiazol-2-yl)carbamate
1g
$ 400.00

Total 2 raw suppliers

Chemical Property of Carbamic acid, [5-(chlorocarbonyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

PKA:4.75±0.70(Predicted)
PSA：96.53000
Density:1.400±0.06 g/cm3(Predicted)
LogP:2.94210

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(5-(chlorocarbonyl)thiazol-2-yl)carbamate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [5-(chlorocarbonyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

There total 3 articles about Carbamic acid, [5-(chlorocarbonyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 302964-02-9
2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid

: 302964-20-1
2-tert-butoxycarbonylamino-1,3-thiazole-5-carboxylic acid chloride

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 24h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 302964-20-1
2-tert-butoxycarbonylamino-1,3-thiazole-5-carboxylic acid chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 4-dimethylaminopyridine / tetrahydrofuran / 18 h

2: aq. KOH / tetrahydrofuran; ethanol / 55 °C

3: oxalyl chloride; DMF / tetrahydrofuran / 4 h / 20 °C

With dmap; potassium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm060727j

Reference yield:

: 302964-01-8
ethyl 2-[(tert-butoxycarbonyl)amino]-1.3-thiazole-5-carboxylate

: 302964-20-1
2-tert-butoxycarbonylamino-1,3-thiazole-5-carboxylic acid chloride

Guidance literature:: Multi-step reaction with 2 steps

1: aq. KOH / tetrahydrofuran; ethanol / 55 °C

2: oxalyl chloride; DMF / tetrahydrofuran / 4 h / 20 °C

With potassium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm060727j