N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine)

Base Information

Chemical Name:N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine)
CAS No.:197636-81-0
Molecular Formula:C₄₂H₅₁N₇O₁₂
Molecular Weight:845.907
Hs Code.:

Synonyms:N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine)

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Technology Process of N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine)

There total 6 articles about N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 162062-69-3
N,N',N''-<(SSS)-Nitrilotris<2-(benzoylamino)-1-oxo-2,1-ethanediyl>>tris trimethyl ester

: 197636-81-0
N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine)

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; 1.) 0 deg C, 3 h, 2.) r.t., 15 h;
DOI:10.1002/chem.19970030813

Reference yield:

: 101649-82-5
N-benzoyl-2-bromoglycine methyl ester

: 197636-81-0
N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine)

Guidance literature:: Multi-step reaction with 4 steps

1: 10 percent / NH₃, Et₃N / tetrahydrofuran / 24 h / Ambient temperature

2: 92 percent / aq. LiOH / methanol / 1.) 0 deg C, 3 h, 2.) r.t., 15 h

3: HOBt, N-ethylmorpholine, EDCl / tetrahydrofuran / 18 h / 0 - 20 °C

4: 93 percent / aq. LiOH / tetrahydrofuran / 1.) 0 deg C, 3 h, 2.) r.t., 15 h

With N-ethylmorpholine;; lithium hydroxide; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1002/chem.19970030813

Reference yield:

: 6306-52-1
L-valine methylester hydrochloride

: 197636-81-0
N,N',N''-{(SSS)-Nitrilotris[2-(benzoylamino)-1-oxo-2,1-ethanediyl]}tris(L-valine)

Guidance literature:: Multi-step reaction with 2 steps

1: HOBt, N-ethylmorpholine, EDCl / tetrahydrofuran / 18 h / 0 - 20 °C

2: 93 percent / aq. LiOH / tetrahydrofuran / 1.) 0 deg C, 3 h, 2.) r.t., 15 h

With N-ethylmorpholine;; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;
DOI:10.1002/chem.19970030813