[(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid

Base Information

Chemical Name:[(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid
CAS No.:114157-67-4
Molecular Formula:C₃₃H₃₃N₃O₁₆
Molecular Weight:727.636
Hs Code.:

[(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid

Synonyms:[(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid

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Chemical Property of [(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid

There total 5 articles about [(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 712-97-0
6-nitro-1,3-benzodioxole-5-carbaldehyde

: 114157-67-4
[(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / 2,6-di-tert-butylpyridine / CHCl₃ / Ambient temperature

2: tetrabutylammonium fluoride trihydrate / CHCl₃ / 0.25 h / Ambient temperature

3: 1M KOH then acid / dioxane; methanol; H₂O

4: pyridine

With pyridine; potassium hydroxide; 2,6-di-tert-butyl-pyridine; tetrabutyl ammonium fluoride; In 1,4-dioxane; methanol; chloroform; water;
DOI:10.1021/ja00218a034

Reference yield:

: 96315-10-5
N-(2-(2-(2-(bis(methoxycarbonylmethyl)amino)phenoxy)ethoxy)-4-methylphenyl)-N-(methoxycarbonylmethyl)aminoacetic acid methyl ester

: 114157-67-4
[(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / 2,6-di-tert-butylpyridine / CHCl₃ / Ambient temperature

2: tetrabutylammonium fluoride trihydrate / CHCl₃ / 0.25 h / Ambient temperature

3: 1M KOH then acid / dioxane; methanol; H₂O

4: pyridine

With pyridine; potassium hydroxide; 2,6-di-tert-butyl-pyridine; tetrabutyl ammonium fluoride; In 1,4-dioxane; methanol; chloroform; water;
DOI:10.1021/ja00218a034

Reference yield:

: ({2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-4-[hydroxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-phenyl}-methoxycarbonylmethyl-amino)-acetic acid methyl ester

: 114157-67-4
[(4-[Acetoxy-(6-nitro-benzo[1,3]dioxol-5-yl)-methyl]-2-{2-[2-(bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-phenyl)-carboxymethyl-amino]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1M KOH then acid / dioxane; methanol; H₂O

2: pyridine

With pyridine; potassium hydroxide; In 1,4-dioxane; methanol; water;
DOI:10.1021/ja00218a034