5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

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Chemical Name:5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide
CAS No.:1429510-97-3
Molecular Formula:C₂₃H₂₅FN₄O₃
Molecular Weight:424.475
Hs Code.:

Synonyms:5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

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Chemical Property of 5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

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Technology Process of 5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

There total 9 articles about 5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429510-96-2
ethyl 5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate

: 1429510-97-3
5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: ethyl 5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate; With water; sodium hydroxide; In ethanol; at 60 - 70 ℃; for 1.05h;

With hydrogenchloride; In chloroform; water;

Reference yield:

: C₂₃H₂₄FN₃O₄

: 1429510-97-3
5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: C₂₃H₂₄FN₃O₄; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 1h; Inert atmosphere;

With ammonia; In water; N,N-dimethyl-formamide; at 10 - 35 ℃; for 5h;

Reference yield:

: 140413-40-7
3-amino-2-chloro-4,6-dimethylpyridine

: 1429510-97-3
5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; hydrogen bromide / water / 0.25 h / 0 °C

1.2: 1.17 h / 0 - 60 °C

2.1: N,N-dimethyl-formamide; methanol / 36 h / 80 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 1.05 h / 60 - 70 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; hydrogen bromide; caesium carbonate; sodium hydroxide; sodium nitrite; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;