(-)-(S_P)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide

Base Information

• Chemical Name: (-)-(S_P)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide
• CAS No.: 77085-89-3
• Molecular Formula: C₂₀H₂₉O₃P
• Molecular Weight: 348.422
• Mol file: 77085-89-3.mol

Synonyms:(-)-(S_P)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide

Chemical Property of (-)-(S_P)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(S_P)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide

There total 2 articles about (-)-(S_P)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

butoxy(phenyl)(vinyl)phosphine (77085-88-2) + (-)-menthyl bromoacetate (16832-20-5,32815-12-6,55284-67-8) → (-)-(menthoxycarbonylmethyl)phenylvinylphosphine oxide (77085-89-3,134369-22-5)

Guidance literature:

at 100 - 105 ℃; for 0.5h;

DOI:10.1016/0040-4020(80)80133-5

Reference yield: 19.1%

butoxy(phenyl)(vinyl)phosphine (77085-88-2) + (1R,2S,5R)-menthol bromoacetate (16832-20-5,32815-12-6,55284-67-8) → (-)-(SP)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide (77085-89-3) + (+)-(RP)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide (134369-22-5)

Guidance literature:

at 115 ℃; for 0.5h; Title compound not separated from byproducts;

DOI:10.1515/znb-1998-0213

Reference yield: 88.0%

(-)-(menthoxycarbonylmethyl)phenylvinylphosphine oxide (77085-89-3,134369-22-5) → (-)-ethyl(menthoxycarbonylmethyl)phenylphosphine oxide (77085-90-6,89496-38-8)

Guidance literature:

Lindlar's catalyst; In methanol; for 0.333333h; Ambient temperature;

DOI:10.1016/0040-4020(80)80133-5

upstream raw materials:

butoxy(phenyl)(vinyl)phosphine

(1R,2S,5R)-menthol bromoacetate

(-)-menthyl bromoacetate

Downstream raw materials:

[(R)-((2R,3aR)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

[(R)-((2S,3aS)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

(-)-(S_P)-methylphenylvinylphosphine oxide

[(R)-(3-Methyl-butyl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester